|
The following Aldactone (spironolactone) adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity:
* Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.
* Endocrine: Gynecomastia (see Precautions), inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding.
* Carcinoma of the breast has been reported in patients taking spironolactone but a cause and effect relationship has not been established.
* Hematologic: Agranulocytosis.
* Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.
* Nervous system /psychiatric: Mental confusion, ataxia, headache, drowsiness, lethargy.
* Liver/biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration.
* Renal: Renal dysfunction (including renal failure).
|
