Premig
lysine acetylsalicylate & metoclopramide
Premig is used for the treatment of migraines in adults.
Premig Composition
The two main ingredients of Premig include lysine acetylsalicylate and metoclopramide. The former ingredient is a soluble form of acetylsalicylic acid, which is a pain killer, alternatively known as aspirin. Metoclopramide is antiemetic drug.
Drug Action
Aspirin belongs to non-steroidal anti inflammatory drug and works by blocking cyclo-oxigenase. Cyclo-oxigenase is responsible for the production of different chemicals in the body importantly the prostaglandins, which are produces in response to injury or any ailments that causes pain, swelling and inflammation. By blocking the prostaglandins, the drug indirectly relieves the body from pain and inflammation. Thus premig relieves the pain due to headaches during migraine.
The second ingredient metoclopramide cures the symptoms of migraine and speed up the aspirin absorption and relieve the person from migraine attacks. The drug blocks the dopamine receptors in the brain termed as chemo-receptor trigger zone. By blocking the dopamine receptors in CTZ zone, the drug prevents the message from being sent to the vomiting center. The drug also acts in the upper gut, which enhances the action of acetylcholine. Increased acetyl choline action causes the muscles to tighten at the stomach entry and also relaxes the muscles at the stomach exit. This action helps in speedy travel of the food from the stomach to the intestine preventing vomiting. The process also helps in fast transfer of aspirin from the stomach to the intestine thus relieving from the migraine pains.
Premig works better when it is administered as soon as the onset of migraine attacks.
Premig Side Effects
The side effects of Premig are uncommon. In rare cases one might experience,
- Drowsiness
- Restlessness
- Fatigue
- Constipation or diarrhea
It is wise to consult the doctor if the side effects persist for a long period.
