|
Furosemide - Lasix belongs to a class of drugs known as diuretics, or "water pills." Lasix happens to be a strong diuretic, and is indicated to treat excess fluid and swelling in the body caused by conditions such as heart failure, kidney failure, and cirrhosis (a liver disease).
Newly discovered Lasix uses (off-label):
Acute asthma, allergen-induced asthma, ascites in cirrhosis, aspirin-sensitive asthma, bronchopulmonary dysplasia (in infants), chronic asthma, membranous nephropathy, nocturia, prevention of exercise-induced bronchospasm, steroid-dependent asthma.
The evidence from many experimental studies suggests that furosemide acts along the entire nephron with the exception of the distal exchange site. The main effect in on the ascending limb of the loop of Henle with a complex effect on renal circulation. Blood-flow is diverted from the juxta-medullary region to the outer cortex. The principle renal action of furosemide is to inhibit active chloride transport in the thick ascending limb. Re-absorption of sodium chloride from the nephron is reduced and a hypotonic or isotonic urine produced.
|
