Diovan
valsartan
Diovan belongs to angiotensin receptor blockers class of drugs. Other drugs under this class include irbesartan (Avapro), losartan (Cozaar), and candesartan (Atacand).
Drug Action
Angiotensin is formed in the blood by the action of angiotensin converting enzyme termed as ACE, which is a powerful chemical that is formed and attaches to the angiotensin receptors found in the tissues especially smooth muscle cells of the blood vessels. The attachment of angiotensin in the muscles causes the blood vessels to constrict, which leads to increase in blood pressure. The drug, Diovan, blocks these angiotensin receptors thus resulting in the dilated blood vessels and reducing the blood pressure simultaneously.
Drug Storage
Diovan is stored at 15 to 30 degree Celsius.
Drug Uses
Diovan is prescribed for treating:
- High blood pressure
- Heart failure
- Reduce death and hospitalization in patients eho have developed congestive heart failure
Diovan Dosage
80 to 160mg of Diovan is given for patients who suffer from high blood pressure. Maximum allowed dose is 320mg per day. Visible reduction of blood vessel can be seen in around 4 weeks. Foe patients suffering from congestive heart failure, 40mg of the drug is given twice daily and dose is gradually increased to 80 to 160mg gradually. 20 mg of drug is given twice daily for patients suffering from heart attacks. The dose should be increased to 160 mg maximum gradually.
Drug administration along with food decreases the drug absorption to 40% , hence the drug works best if it is taken empty stomach.
Drug Interaction
Diovan interacts with:
- Potassium-sparing diuretics like spironolactone, triamterene, amiloride
- Potassium supplements
- Salt substitutes containing potassium may lead to hyperkalemia, and heart failure patients,. The drug also increases serum creatinine level
Pregnancy
Diovan if used in second and third trimester might harm the fetus and can even cause death of the fetus. Hence the drug should not be used in pregnant mothers.
Diovan is also not allowed in breast feeding mothers and should consult doctor in either case.
Diovan Side Effects
Some of the side effects of Diovan include:
- Dizziness
- Fatigue
- Abdominal pain
- Cough
- Diarrhea and nausea
- Hyperkalemia
- Impotence
- Reduced function
- Allergic reactions
Some of the rare side effects include:
- Rhabdomyolysis, which is inflammation and destruction of muscles
- Angioedema, which is swelling of soft tissues including those of the throat and larynx
