Aspirin + Metoclopramide - Premig head ache relief drug profile

Pharmaceutical (Substance) Name: Acetylsalicylate lysine + Metoclopramide

Common Brand/Trade/Commercial denominations: Premig

Manufacturer: Sanofi-Synthelabo

Acetylsalicylate lysine (Aspirin)

Systematic (IUPAC) name: 2-acetoxybenzoic acid
CAS number: 50-78-2
ATC code: A01AD05 B01AC06, N02BA01

Molecular formula: C9H8O4
Molecular weight: 180.157 g/mol

Protein binding: 99.6%
Bioavailability: Rapidly and completely absorbed
Active (Half) Life: 300–650 mg dose: 3.1–3.2 h; 1g dose: 5 h, 2g dose: 9 h
Excretion: Renal

Metoclopramide (Maxolon, Reglan, Degan, Maxeran, Primperan, Pylomid)

Systematic (IUPAC) name: 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- 2-methoxybenzamide
CAS number: 364-62-5
ATC code: A03FA01

Molecular formula: C14H22ClN3O2
Molecular weight: 299.80 g/mol

Bioavailability: 80±15% (oral)
Active (Half) Life: 5–6 hours
Excretion: 70–85% renal, 2% faecal

Premig drug category: head ache and migraine relief

This article was published on Tuesday 07 July, 2009.
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